Multiple mechanisms of antimicrobial resistance in Pseudomonas aeruginosa: Our worst nightmare?

Livermore, David M. ORCID: https://orcid.org/0000-0002-9856-3703 (2002) Multiple mechanisms of antimicrobial resistance in Pseudomonas aeruginosa: Our worst nightmare? Clinical Infectious Diseases, 34 (5). pp. 634-640. ISSN 1058-4838

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Abstract

Pseudomonas aeruginosa carries multiresistance plasmids less often than does Klebsiella pneumoniae, develops mutational resistance to cephalosporins less readily than Enterobacter species, and has less inherent resistance than Stenotrophomonas maltophilia. What nevertheless makes P. aeruginosa uniquely problematic is a combination of the following: the species' inherent resistance to many drug classes; its ability to acquire resistance, via mutations, to all relevant treatments; its high and increasing rates of resistance locally; and its frequent role in serious infections. A few isolates of P. aeruginosa are resistant to all reliable antibiotics, and this problem seems likely to grow with the emergence of integrins that carry gene cassettes encoding both carbapenemases and amikacin acetyltransferases.

Item Type:	Article
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Public Health and Health Services Research (former - to 2023) Faculty of Medicine and Health Sciences > Research Groups > Epidemiology and Public Health
Depositing User:	Rhiannon Harvey
Date Deposited:	11 Jul 2011 11:17
Last Modified:	12 Jan 2024 01:25
URI:	https://ueaeprints.uea.ac.uk/id/eprint/33491
DOI:	10.1086/338782

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