Tools
ToolsWoodford, Neil, Ellington, Matthew J., Coelho, Juliana, Turton, Jane F., Ward, M. Elaina, Brown, Susan, Amyes, Sebastian G. B. and Livermore, David M. (2006) Multiplex PCR for genes encoding prevalent OXA carbapenemases in Acinetobacter spp. International Journal of Antimicrobial Agents, 27 (4). pp. 351-353. ISSN 1872-7913
Full text not available from this repository. (Request a copy)Abstract
Carbapenem resistance in Acinetobacter baumannii is a growing public health concern and is most often mediated by OXA carbapenemases. We describe a novel multiplex polymerase chain reaction (PCR) assay able to detect and distinguish alleles encoding three subgroups of acquired OXA carbapenemases (OXA-23-like, OXA-24-like and OXA-58-like) that are scattered in Acinetobacter spp., and a fourth subgroup, OXA-51-like, which appears to be intrinsic to Acinetobacter baumannii. Isolates belonging to two prevalent UK A. baumannii ‘OXA’ clones (OXA-23 clones 1 and 2) had alleles encoding both an intrinsic OXA-51-like and an acquired OXA-23 enzyme, whereas isolates of the ‘SE clone’ had only an intrinsic blaOXA-51-like allele. Genes encoding OXA-58 were detected (with blaOXA-51-like) in a cluster of related isolates from a single hospital. This simple assay will assist in monitoring the mechanisms responsible for carbapenem resistance in Acinetobacter spp.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Groups > Public Health and Health Services Research (former - to 2023) Faculty of Medicine and Health Sciences > Research Groups > Epidemiology and Public Health |
| Depositing User: | Rhiannon Harvey |
| Date Deposited: | 11 Jul 2011 10:40 |
| Last Modified: | 06 Feb 2025 02:55 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/33480 |
| DOI: | 10.1016/j.ijantimicag.2006.01.004 |
Actions (login required)
 |
View Item |