In vivo development of ertapenem resistance in a patient with pneumonia caused by Klebsiella pneumoniae with an extended-spectrum beta-lactamase

Elliott, Eugenne, Brink, Adrian J., van Greune, Johan, Els, Zia, Woodford, Neil, Turton, Jane, Warner, Marina and Livermore, David M. (2006) In vivo development of ertapenem resistance in a patient with pneumonia caused by Klebsiella pneumoniae with an extended-spectrum beta-lactamase. Clinical Infectious Diseases, 42 (11). E95-E98. ISSN 1058-4838

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Abstract

Four sequential extended-spectrum ß-lactamase—producing isolates of Klebsiella pneumoniae were obtained from a patient after treatment with ertapenem and cultured. The first and fourth isolates were susceptible to ertapenem, whereas the second and third were resistant. All 4 isolates belonged to the same strain and produced a group 1 CTX-M enzyme; additionally, the resistant isolates had lost a porin.

Item Type:	Article
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Public Health and Health Services Research (former - to 2023) Faculty of Medicine and Health Sciences > Research Groups > Epidemiology and Public Health
Depositing User:	Rhiannon Harvey
Date Deposited:	11 Jul 2011 09:59
Last Modified:	21 Oct 2025 23:36
URI:	https://ueaeprints.uea.ac.uk/id/eprint/33469
DOI:	10.1086/503264

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