UK epidemic Escherichia coli strains A-E, with CTX-M-15 β-lactamase, all belong to the international O25:H4-ST131 clone

Lau, Siu Ha, Kaufmann, Mary E., Livermore, David M. ORCID: https://orcid.org/0000-0002-9856-3703, Woodford, Neil, Willshaw, Geraldine A, Cheasty, Tom, Stamper, Katie, Reddy, Suganya, Cheesbrough, John, Bolton, Frederick J., Fox, Andrew J. and Upton, Mathew (2008) UK epidemic Escherichia coli strains A-E, with CTX-M-15 β-lactamase, all belong to the international O25:H4-ST131 clone. Journal of Antimicrobial Chemotherapy, 62 (6). pp. 1241-1244. ISSN 0305-7453

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Abstract

Objectives Uropathogenic and invasive Escherichia coli O25:H4-ST131 isolates producing CTX-M-15 extended-spectrum ß-lactamase (ESBL) enzymes have recently been shown to be disseminated across the globe. In the UK, many CTX-M-15 ESBL-producing E. coli strains have been previously defined as belonging to the epidemic strains A–E, as determined by PFGE. The present study was carried out to define the relationship between these two groups of pathogenic E. coli. Methods Multilocus sequence typing and PFGE were used for molecular characterization of a collection of 61 ESBL-producing E. coli isolates from across the UK. Results Strains A to E all belonged to the ST131 clone, further underscoring the epidemiological importance of this lineage. Conclusions The future spread of the ST131 clone, and its UK variants, should be monitored closely and the pathogenic mechanisms explaining their success should be investigated.

Item Type:	Article
Uncontrolled Keywords:	bacterial typing techniques,cluster analysis,dna fingerprinting,electrophoresis, gel, pulsed-field,escherichia coli,escherichia coli infections,genotype,great britain,humans,molecular epidemiology,sequence analysis, dna,serotyping,beta-lactamases
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Epidemiology and Public Health Faculty of Medicine and Health Sciences > Research Groups > Public Health and Health Services Research (former - to 2023)
Depositing User:	Rhiannon Harvey
Date Deposited:	07 Jul 2011 11:03
Last Modified:	11 Jan 2024 01:22
URI:	https://ueaeprints.uea.ac.uk/id/eprint/33440
DOI:	10.1093/jac/dkn380

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