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Livermore, David M. 
ORCID: https://orcid.org/0000-0002-9856-3703, Mushtaq, Shazad, Warner, Marina and Woodford, Neil
(2009)
Activity of oxazolidinone TR-700 against linezolid-susceptible and -resistant staphylococci and enterococci.
Journal of Antimicrobial Chemotherapy, 63 (4).
pp. 713-715.
ISSN 0305-7453
Abstract
Background: TR-700 is the active moiety of TR-701 (DA-7157), a new oral/intravenous oxazolidinone prodrug. We examined its activity against linezolid-susceptible and -resistant staphylococci and enterococci. Methods: MICs were determined by the CLSI agar dilution method. Results: MICs of TR-700 were tightly clustered around 0.5 mg/L for linezolid-susceptible staphylococci and enterococci compared with 2 mg/L for linezolid. MICs for 52 linezolid-resistant isolates were raised, but only exceeded 4 mg/L for two Enterococcus faecium isolates homozygous for the G2576T 23S rRNA mutation and for one with an unknown mechanism of linezolid resistance. Conclusions: TR-700 is 4- to 16-fold more active than linezolid and overcame most linezolid resistance in vitro.
| Item Type: | Article |
|---|---|
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Groups > Public Health and Health Services Research (former - to 2023) Faculty of Medicine and Health Sciences > Research Groups > Epidemiology and Public Health |
| Depositing User: | Rhiannon Harvey |
| Date Deposited: | 05 Jul 2011 11:14 |
| Last Modified: | 05 Jan 2023 14:30 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/33354 |
| DOI: | 10.1093/jac/dkp002 |
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