Novel polymer-bound aminoalcohol ligands for the asymmetric addition of diethylzinc to aldehydes

Bulman Page, P. C. B., Allin, S. M., Dilly, S. J. and Buckley, B. R. (2007) Novel polymer-bound aminoalcohol ligands for the asymmetric addition of diethylzinc to aldehydes. Synthetic Communications, 37 (12). pp. 2019-2030. ISSN 0039-7911

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Abstract

The synthesis of several novel polymer-supported aziridine- containing aminoalcohol chiral ligands has been accomplished, and the polymers have been used as ligands for the catalytic asymmetric addition of diethylzinc to benzaldehyde, giving up to 89% ee. Incorporation onto a polymer support prevents the variation of ee with time that is observed in reactions of one unsupported ligand, perhaps as a result of site isolation of the ligand within the polymer, preventing cooperative effects.

Item Type:	Article
Uncontrolled Keywords:	catalysts,alkylation,aminoalcohol,ligand,dialkylzincs,addition,alcohols,aldehyde,benzaldehyde,asymmetric dialkyl zinc,carbonyl-compounds,enantioselective addition,self
Faculty \ School:	Faculty of Science > School of Chemistry (former - to 2024)
UEA Research Groups:	Faculty of Science > Research Groups > Synthetic Chemistry (former - to 2017) Faculty of Science > Research Groups > Chemistry of Materials and Catalysis
Depositing User:	Rachel Smith
Date Deposited:	20 Jun 2011 13:41
Last Modified:	24 Sep 2024 09:39
URI:	https://ueaeprints.uea.ac.uk/id/eprint/32881
DOI:	10.1080/00397910701356553

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