A new asymmetric synthesis of the anti-tumor alkaloid (R)-(+)-Crispine A

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Allin, Steven M., Gaskell, Sean N., Towler, Joannah M. R., Bulman Page, Philip C., Saha, Basu, McKenzie, Michael J. and Martin, William P. (2007) A new asymmetric synthesis of the anti-tumor alkaloid (R)-(+)-Crispine A. The Journal of Organic Chemistry, 72 (23). pp. 8972-8975. ISSN 0022-3263

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Abstract

We report a novel, facile, and asymmetric approach for the synthesis of the anti-tumor alkaloid (+)-crispine A via a highly diastereoselective N-acyliminium cyclization reaction as a key synthetic step.

Item Type:	Article
Uncontrolled Keywords:	acyliminium ion cyclization,-)-crispine-a,alpha-amidoalkylation reactions,derivatives,enantiomers,pyrroloisoquinoline ring-system,facile,stereoselective synthesis,enantioselective synthesis
Faculty \ School:	Faculty of Science > School of Chemistry (former - to 2024)
UEA Research Groups:	Faculty of Science > Research Groups > Chemistry of Materials and Catalysis Faculty of Science > Research Groups > Synthetic Chemistry (former - to 2017)
Depositing User:	Rachel Smith
Date Deposited:	20 Jun 2011 14:57
Last Modified:	24 Sep 2024 09:38
URI:	https://ueaeprints.uea.ac.uk/id/eprint/32878
DOI:	10.1021/jo071235x

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