Simple synthesis of oxiranylidene-2,2-bis(phosphonic acid): Tetrabenzyl geminal bisphosphonate esters as useful intermediates

Bulman Page, P. C. B., McKenzie, M. J. and Gallagher, J. A. (2002) Simple synthesis of oxiranylidene-2,2-bis(phosphonic acid): Tetrabenzyl geminal bisphosphonate esters as useful intermediates. Synthetic Communications, 32 (2). pp. 211-218. ISSN 0039-7911

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Abstract

Tetrabenzyl geminal bisphosphonate esters are shown to be useful synthetic equivalents of 1,1-bis(phosphonic acid)s which may be easily functionalized at the central carbon atom without phosphonate ester hydrolysis. The parent bis(phosphonic acid) unit is readily regenerated by hydrogenolysis. The chemistry is used to prepare the elusive epoxide oxiranylidene-2,2-bis(phosphonic acid) by a short and reliable procedure.

Item Type: Article
Uncontrolled Keywords: inhibitor,breast-cancer,agents,osteoporosis,bone-resorption,analogs,ovariectomized rats,postmenopausal women,mechanisms,osteoblasts,sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School: Faculty of Science > School of Chemistry
Depositing User: Rachel Smith
Date Deposited: 21 Jun 2011 10:25
Last Modified: 26 Sep 2022 03:45
URI: https://ueaeprints.uea.ac.uk/id/eprint/32840
DOI:

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