Synthesis of bone-targeted oestrogenic compounds for the inhibition of bone resorption

Bulman Page, Philip C., Moore, Jonathan P. G., Mansfield, Ian, McKenzie, Michael J., Bowler, Wayne B. and Gallagher, James A. (2001) Synthesis of bone-targeted oestrogenic compounds for the inhibition of bone resorption. Tetrahedron, 57 (9). pp. 1837-1847. ISSN 0040-4020

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Abstract

Syntheses have been realised for several members of a new class of potential bone resorption inhibitors consisting of steroidal oestrogenic compounds linked at the 17 position to a geminal bia(phosphonic acid) moiety through an ester linkage. The approach used has the potential to allow other biologically active compounds to be coupled to the geminal bisphosphonate unit. (C) 2001 Elsevier Science Ltd. All rights reserved.

Item Type:	Article
Uncontrolled Keywords:	risk,bisphosphonate,targeting,osteoporosis,oestrogen,estrogen,bisphosphonates,breast-cancer,alendronate,ovariectomized rats,postmenopausal women,osteoblasts,mechanisms,sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School:	Faculty of Science > School of Chemistry (former - to 2024)
UEA Research Groups:	Faculty of Science > Research Groups > Chemistry of Materials and Catalysis Faculty of Science > Research Groups > Synthetic Chemistry (former - to 2017)
Depositing User:	Rachel Smith
Date Deposited:	21 Jun 2011 11:21
Last Modified:	24 Sep 2024 10:22
URI:	https://ueaeprints.uea.ac.uk/id/eprint/32828
DOI:	10.1016/S0040-4020(00)01164-9

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