The reductive cleavage of cyclic aminol ethers to N,N-dialkylaminoderivatives: Modifications to the Eschweiler-Clarke procedure

Bulman Page, Philip C., Heaney, Harry, Rassias, Gerasimos A., Reignier, Serge, Sampler, Edward P. and Talib, Salem (2000) The reductive cleavage of cyclic aminol ethers to N,N-dialkylaminoderivatives: Modifications to the Eschweiler-Clarke procedure. Synlett, 2000 (1). pp. 104-106. ISSN 0936-5214

Full text not available from this repository.

Abstract

The reductive cleavage of cyclic aminol ethers to give N-alkylamino- derivatives in very high yields can be achieved using chlorotrimethylsilane in the presence of sodium cyanoborohydride: in the case of cyclic aminol ethers derived from formaldehyde the Eschweiler-Clarke reaction can be carried out in formic acid heated under reflux in the absence of formaldehyde.

Item Type:	Article
Uncontrolled Keywords:	ring opening,chlorotrimethylsilane,secondary,1,sodium cyanoborohydride,asymmetric-synthesis,reductive,3-oxazolidines,chiral heterocycles,aminol ethers
Faculty \ School:	Faculty of Science > School of Chemistry (former - to 2024)
UEA Research Groups:	Faculty of Science > Research Groups > Chemistry of Materials and Catalysis Faculty of Science > Research Groups > Synthetic Chemistry (former - to 2017)
Depositing User:	Rachel Smith
Date Deposited:	21 Jun 2011 11:42
Last Modified:	24 Sep 2024 10:26
URI:	https://ueaeprints.uea.ac.uk/id/eprint/32811
DOI:	10.1055/s-2000-6459

Actions (login required)

View Item