A convenient one-step synthesis of L-aminotryptophans and improved synthesis of 5-fluorotryptophan

Winn, Michael, Roy, Abhijeet D., Grüschow, Sabine, Parameswaran, Raj S. and Goss, Rebecca J. M. (2008) A convenient one-step synthesis of L-aminotryptophans and improved synthesis of 5-fluorotryptophan. Bioorganic & Medicinal Chemistry Letters, 18 (16). pp. 4508-4510. ISSN 0960-894X

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Abstract

A one-pot biotransformation for the generation of a series of L-aminotryptophans using a readily prepared protein extract containing tryptophan synthase is reported. The extract exhibits remarkable stability upon freeze-drying, and may be stored and used for long periods after its preparation without significant loss of activity.

Item Type:	Article
Uncontrolled Keywords:	design,state,genetic-code,preparation,tryptophan synthase,halotryptophan,aminotryptophan,biotransformation,tryptophan synthase,antibiotics
Faculty \ School:	Faculty of Science > School of Chemistry
Depositing User:	Rachel Smith
Date Deposited:	16 Jun 2011 09:35
Last Modified:	24 Oct 2022 01:08
URI:	https://ueaeprints.uea.ac.uk/id/eprint/32659
DOI:	10.1016/j.bmcl.2008.07.053

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