Generating rapamycin analogues by directed biosynthesis: starter acid substrate specificity of mono-substituted cyclohexane carboxylic acids

Goss, Rebecca J. M., Lanceron, Simon E., Wise, Nicola J. and Moss, Steven J. (2006) Generating rapamycin analogues by directed biosynthesis: starter acid substrate specificity of mono-substituted cyclohexane carboxylic acids. Organic & Biomolecular Chemistry, 4 (22). pp. 4071-4073. ISSN 1477-0520

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Abstract

We report a convenient synthesis of 4-fluorocyclohexanoic acid, and an insight into the rules governing acceptance of starter acid analogues in the precursor-directed biosynthesis of rapamycin.

Item Type:	Article
Faculty \ School:	Faculty of Science > School of Chemistry Faculty of Science > School of Chemical Sciences and Pharmacy (former - to 2009)
Depositing User:	Rachel Smith
Date Deposited:	16 Jun 2011 10:01
Last Modified:	23 Oct 2022 09:30
URI:	https://ueaeprints.uea.ac.uk/id/eprint/32653
DOI:	10.1039/b614519c

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