Cachexia in chronic heart failure: Prognostic implications and novel therapeutic approaches

Akashi, Yoshihiro J., Springer, Jochen and Anker, Stefan D. (2005) Cachexia in chronic heart failure: Prognostic implications and novel therapeutic approaches. Current Heart Failure Reports, 2 (4). pp. 198-203. ISSN 1546-9530

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Abstract

Cachexia in patients with chronic heart failure (CHF) has been recognized for a long time; however, it has not received much attention until recently. Cardiac cachexia, a common and serious complication of CHF, is associated with very poor prognosis. Several studies have demonstrated that increased neurohormonal and immune abnormalities may play a crucial role in the pathophysiology of cardiac cachexia. Hormonal and catabolic/anabolic imbalances of the body are likely to be responsible for the development of cachexia in CHF. Recently, ghrelin, a novel growth hormone-releasing peptide, has been widely noticed to have potential in the treatment of severe CHF and cardiac cachexia. However, further research will be necessary to identify the exact pathways involved and to find the best therapeutic strategies of using ghrelin to fight the wasting process.

Item Type:	Article
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Gastroenterology and Gut Biology
Depositing User:	Rhiannon Harvey
Date Deposited:	09 Jun 2011 15:44
Last Modified:	17 Feb 2023 16:30
URI:	https://ueaeprints.uea.ac.uk/id/eprint/32181
DOI:	10.1007/BF02696650

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