Muscle wasting in cardiac cachexia

Strassburg, Sabine, Springer, Jochen and Anker, Stefan D. (2005) Muscle wasting in cardiac cachexia. International Journal of Biochemistry & Cell Biology, 37 (10). pp. 1938-1947. ISSN 1878-5875

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Abstract

Cardiac cachexia is a serious complication of chronic heart failure which is characterized by complex changes that overall lead to a catabolic/anabolic imbalance resulting in body wasting and a poor prognosis. The wasting process affects all body components, but particularly the skeletal musculature, causing extreme fatigue and weakness, especially in cachectic heart failure patients. Available evidence suggests that several pathophysiologic pathways play a role in the muscle wasting process. Metabolic, neurohormonal, and immune abnormalities lead to an altered regulation of proliferation, differentiation, apoptosis, and metabolism in skeletal muscle, finally resulting in deterioration of the underlying cause with symptomatic exercise intolerance. Possible treatment strategies against muscle wasting and cachexia in chronic heart failure are also described here. As there is no validated therapy for cardiac cachexia yet, further research is necessary to find more therapeutic options for the wasting process.

Item Type:	Article
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Gastroenterology and Gut Biology
Depositing User:	Rhiannon Harvey
Date Deposited:	09 Jun 2011 15:42
Last Modified:	17 Feb 2023 16:30
URI:	https://ueaeprints.uea.ac.uk/id/eprint/32180
DOI:	10.1016/j.biocel.2005.03.013

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