PTH circadian rhythm and PTH target-organ sensitivity is altered in patients with adult growth hormone deficiency with low BMD

White, Helen D., Ahmad, Aftab M., Durham, Brian H., Peter, Rajesh, Prabhakar, V. Karthik B., Corlett, Pamela, Vora, Jiten P. and Fraser, William D. (2007) PTH circadian rhythm and PTH target-organ sensitivity is altered in patients with adult growth hormone deficiency with low BMD. Journal of Bone and Mineral Research, 22 (11). pp. 1798-1807. ISSN 1523-4681

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Abstract

AGHD is associated with osteoporosis. We examined PTH circadian rhythmicity and PTH target-organ sensitivity in 23 patients with AGHD with low BMD and 20 patients with AGHD with normal BMD. Patients with low BMD had a blunted nocturnal rise in PTH concentration and reduced PTH target-organ sensitivity compared with patients with normal BMD; these factors may be important in the pathogenesis of AGHD-related osteoporosis.

Item Type:	Article
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Musculoskeletal Medicine Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health
Depositing User:	Rhiannon Harvey
Date Deposited:	08 Jun 2011 13:42
Last Modified:	24 Sep 2024 09:37
URI:	https://ueaeprints.uea.ac.uk/id/eprint/32073
DOI:	10.1359/jbmr.070715

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