The physiology of the circadian rhythm of parathyroid hormone and its potential as a treatment for osteoporosis

Fraser, William D, Ahmad, Aftab M and Vora, Jiten P (2004) The physiology of the circadian rhythm of parathyroid hormone and its potential as a treatment for osteoporosis. Current Opinion in Nephrology and Hypertension, 13 (4). pp. 437-444. ISSN 1062-4821

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Abstract

The circadian nature of parathyroid hormone secretion is confirmed by many publications. The underlying rhythm is endogenous. Life style factors and nutritional intake modulate the pattern of secretion. Direct association with bone resorption and formation is tentative. It is suggested that acute changes in these rhythms have little effect on resorption, but longer-term manipulation of parathyroid hormone secretion alters bone cell function. Growth hormone therapy in adult deficiency increases parathyroid hormone activity, indicating growth hormone may have therapeutic potential for osteoporosis. Manipulation of the endogenous parathyroid hormone rhythm, using timed supplements of phosphate or calcium or by calcilytic and calcimimetic molecules, offers a novel approach to osteoporosis treatment.

Item Type:	Article
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Musculoskeletal Medicine Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health
Depositing User:	Rhiannon Harvey
Date Deposited:	08 Jun 2011 11:46
Last Modified:	19 Oct 2023 00:56
URI:	https://ueaeprints.uea.ac.uk/id/eprint/32035
DOI:	10.1097/01.mnh.0000133985.29880.34

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