Dietary Alpha-Tocopherol Affects Differential Gene Expression in Rat Testes

Rota, Cristina, Barella, Luca, Minihane, Anne Marie ORCID:, Stöcklin, Elisabeth and Rimbach, Gerald (2004) Dietary Alpha-Tocopherol Affects Differential Gene Expression in Rat Testes. IUBMB Life (International Union of Biochemistry and Molecular Biology: Life), 56 (5). pp. 277-280. ISSN 1521-6543

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Gene-chip technology was employed to study the effect of dietary vitamin E (VE) on gene expression in rat testes. Male albino rats were fed with either a diet deficient in VE or a standard diet containing VE. Differential gene expression was monitored at five individual time-points over a period of 14 months with all animals individually profiled. Low VE intake resulted in the consistent up-regulation of 7-dehydrocholesterol reductase and GATA binding protein 4, both involved in testosterone synthesis. Cyclin D3, important in cell cycle progression and Wilms tumor 1, related to cancer development, were also up-regulated in the vitamin E deficient animals. This study demonstrates that low dietary VE intake has long-term effects on gene expression in the testes. Our data provides insights into the possible molecular mechanisms underlying the beneficial effects of vitamin E on the male reproductive organ.

Item Type: Article
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Rhiannon Harvey
Date Deposited: 01 Jun 2011 08:25
Last Modified: 02 Mar 2023 12:30
DOI: 10.1080/15216540410001724133

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