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Rota, Cristina, Barella, Luca, Minihane, Anne Marie 
ORCID: https://orcid.org/0000-0001-9042-4226, Stöcklin, Elisabeth and Rimbach, Gerald
(2004)
Dietary alpha-tocopherol affects differential gene expression in rat testes.
IUBMB Life (International Union of Biochemistry and Molecular Biology: Life), 56 (5).
pp. 277-280.
ISSN 1521-6543
Abstract
Gene-chip technology was employed to study the effect of dietary vitamin E (VE) on gene expression in rat testes. Male albino rats were fed with either a diet deficient in VE or a standard diet containing VE. Differential gene expression was monitored at five individual time-points over a period of 14 months with all animals individually profiled. Low VE intake resulted in the consistent up-regulation of 7-dehydrocholesterol reductase and GATA binding protein 4, both involved in testosterone synthesis. Cyclin D3, important in cell cycle progression and Wilms tumor 1, related to cancer development, were also up-regulated in the vitamin E deficient animals. This study demonstrates that low dietary VE intake has long-term effects on gene expression in the testes. Our data provides insights into the possible molecular mechanisms underlying the beneficial effects of vitamin E on the male reproductive organ.
| Item Type: | Article |
|---|---|
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Groups > Nutrition and Preventive Medicine Faculty of Medicine and Health Sciences > Research Groups > Cardiovascular and Metabolic Health Faculty of Medicine and Health Sciences > Research Centres > Lifespan Health |
| Depositing User: | Rhiannon Harvey |
| Date Deposited: | 01 Jun 2011 08:25 |
| Last Modified: | 19 Oct 2023 00:56 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/31649 |
| DOI: | 10.1080/15216540410001724133 |
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