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Majewicz, Jonathan, Rimbach, Gerald, Proteggente, Anna R., Lodge, John K., Kraemer, Klaus and Minihane, Anne M 
ORCID: https://orcid.org/0000-0001-9042-4226
(2005)
Dietary vitamin C down-regulates inflammatory gene expression in apoE4 smokers.
Biochemical and Biophysical Research Communications, 338 (2).
pp. 951-955.
ISSN 1090-2104
Abstract
The deleterious impact of cigarette smoking on cardiovascular health may be in part attributable to a free radical mediated proinflammatory response in circulating monocytes. In the current investigation, the impact of vitamin C supplementation on monocyte gene expression was determined in apoE4 smokers versus non-smokers. A total of 10 smokers and 11 non-smokers consumed 60 mg/day of vitamin C for four weeks and a fasting blood sample was taken at baseline and post-intervention for the determination of plasma vitamin C and monocyte gene expression profiles using cDNA array and real time PCR. In apoE4 smokers, supplementation resulted in a 43% increase in plasma vitamin C concentrations. Furthermore, a number of genes were differentially expressed more than 2-fold in response to treatment, including a downregulation of the proinflammatory mediators tumor necrosis factor (TNF) β, TNF receptor, neurotrophin-3 growth factor receptor, and monocyte chemoattractant protein 1 receptor. The study has identified a number of molecular mechanisms underlying the benefit of vitamin C supplementation in smokers.
| Item Type: | Article |
|---|---|
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| Depositing User: | Rhiannon Harvey |
| Date Deposited: | 01 Jun 2011 08:06 |
| Last Modified: | 17 Feb 2023 16:30 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/31643 |
| DOI: | 10.1016/j.bbrc.2005.10.029 |
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