Dietary vitamin C down-regulates inflammatory gene expression in apoE4 smokers

Majewicz, Jonathan, Rimbach, Gerald, Proteggente, Anna R., Lodge, John K., Kraemer, Klaus and Minihane, Anne M ORCID: https://orcid.org/0000-0001-9042-4226 (2005) Dietary vitamin C down-regulates inflammatory gene expression in apoE4 smokers. Biochemical and Biophysical Research Communications, 338 (2). pp. 951-955. ISSN 1090-2104

Full text not available from this repository. (Request a copy)

Abstract

The deleterious impact of cigarette smoking on cardiovascular health may be in part attributable to a free radical mediated proinflammatory response in circulating monocytes. In the current investigation, the impact of vitamin C supplementation on monocyte gene expression was determined in apoE4 smokers versus non-smokers. A total of 10 smokers and 11 non-smokers consumed 60 mg/day of vitamin C for four weeks and a fasting blood sample was taken at baseline and post-intervention for the determination of plasma vitamin C and monocyte gene expression profiles using cDNA array and real time PCR. In apoE4 smokers, supplementation resulted in a 43% increase in plasma vitamin C concentrations. Furthermore, a number of genes were differentially expressed more than 2-fold in response to treatment, including a downregulation of the proinflammatory mediators tumor necrosis factor (TNF) β, TNF receptor, neurotrophin-3 growth factor receptor, and monocyte chemoattractant protein 1 receptor. The study has identified a number of molecular mechanisms underlying the benefit of vitamin C supplementation in smokers.

Item Type:	Article
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Nutrition and Preventive Medicine Faculty of Medicine and Health Sciences > Research Groups > Cardiovascular and Metabolic Health Faculty of Medicine and Health Sciences > Research Centres > Lifespan Health
Depositing User:	Rhiannon Harvey
Date Deposited:	01 Jun 2011 08:06
Last Modified:	19 Oct 2023 00:53
URI:	https://ueaeprints.uea.ac.uk/id/eprint/31643
DOI:	10.1016/j.bbrc.2005.10.029

Actions (login required)

View Item