Cigarette smokers differ in their handling of natural (RRR) and synthetic (all rac) alpha-tocopherol:a biokinetic study in apoE4 male subjects

Proteggente, Anna R, Rota, Cristina, Majewicz, John, Rimbach, Gerald, Minihane, Anne-Marie, Kraemer, Klaus and Lodge, John K (2006) Cigarette smokers differ in their handling of natural (RRR) and synthetic (all rac) alpha-tocopherol:a biokinetic study in apoE4 male subjects. Free Radical Biology & Medicine, 40 (12). pp. 2080-2091. ISSN 0891-5849

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Abstract

We have compared the biokinetics of deuterated natural (RRR) and synthetic (all rac) alpha-tocopherol in male apoE4-carrying smokers and nonsmokers. In a randomized, crossover study subjects underwent two 4-week treatments (400 mg/day) with undeuterated RRR- and all rac-alpha-tocopheryl acetate around a 12-week washout. Before and after each supplementation period subjects underwent a biokinetic protocol (48 h) with 150 mg deuterated RRR- or all rac-alpha-tocopheryl acetate. During the biokinetic protocols, the elimination of endogenous plasma alpha-tocopherol was significantly faster in smokers (P

Item Type: Article
Uncontrolled Keywords: adult,alzheimer disease,apolipoprotein e4,apolipoproteins e,ascorbic acid,chromans,coronary disease,f2-isoprostanes,genetic predisposition to disease,humans,hyperlipoproteinemia type v,male,middle aged,smoking,tocopherols,alpha-tocopherol
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Related URLs:
Depositing User: Rhiannon Harvey
Date Deposited: 31 May 2011 15:52
Last Modified: 27 Apr 2020 23:44
URI: https://ueaeprints.uea.ac.uk/id/eprint/31641
DOI: 10.1016/j.freeradbiomed.2006.02.006

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