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Proteggente, Anna R, Rota, Cristina, Majewicz, John, Rimbach, Gerald, Minihane, Anne-Marie 
ORCID: https://orcid.org/0000-0001-9042-4226, Kraemer, Klaus and Lodge, John K
(2006)
Cigarette smokers differ in their handling of natural (RRR) and synthetic (all rac) alpha-tocopherol: a biokinetic study in apoE4 male subjects.
Free Radical Biology & Medicine, 40 (12).
pp. 2080-2091.
ISSN 0891-5849
Abstract
We have compared the biokinetics of deuterated natural (RRR) and synthetic (all rac) alpha-tocopherol in male apoE4-carrying smokers and nonsmokers. In a randomized, crossover study subjects underwent two 4-week treatments (400 mg/day) with undeuterated RRR- and all rac-alpha-tocopheryl acetate around a 12-week washout. Before and after each supplementation period subjects underwent a biokinetic protocol (48 h) with 150 mg deuterated RRR- or all rac-alpha-tocopheryl acetate. During the biokinetic protocols, the elimination of endogenous plasma alpha-tocopherol was significantly faster in smokers (P
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | adult,alzheimer disease,apolipoprotein e4,apolipoproteins e,ascorbic acid,chromans,coronary disease,f2-isoprostanes,genetic predisposition to disease,humans,hyperlipoproteinemia type v,male,middle aged,smoking,tocopherols,alpha-tocopherol |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Groups > Nutrition and Preventive Medicine Faculty of Medicine and Health Sciences > Research Groups > Cardiovascular and Metabolic Health Faculty of Medicine and Health Sciences > Research Centres > Lifespan Health |
| Depositing User: | Rhiannon Harvey |
| Date Deposited: | 31 May 2011 15:52 |
| Last Modified: | 19 Oct 2023 00:50 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/31641 |
| DOI: | 10.1016/j.freeradbiomed.2006.02.006 |
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