The CXC chemokine MIG/CXCL9 is important in innate immunity against Streptococcus pyogenes

Egesten, Arne, Eliasson, Mette, Johansson, Helena M., Olin, Anders I., Mörgelin, Matthias, Mueller, Anja ORCID:, Pease, James E., Frick, Inga-Maria and Björck, Lars (2007) The CXC chemokine MIG/CXCL9 is important in innate immunity against Streptococcus pyogenes. Journal of Infectious Diseases, 195 (5). pp. 684-693. ISSN 0022-1899

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Pharyngitis caused by Streptococcus pyogenes is one of the most common bacterial infections in humans and is also a starting point for invasive S. pyogenes infection. Here, we describe that tonsil fluid from patients with streptococcal pharyngitis contains high amounts of the interferon ( IFN)-dependent CXC chemokine known as monokine induced by IFN-gamma ( MIG)/CXCL9. Also in vitro, inflamed pharyngeal epithelium produced large amounts of MIG/CXCL9 in the presence of bacteria. The CXC chemokines MIG/CXCL9, IFN-inducible protein-10/CXCL10, and IFN-inducible T cell alpha-chemoattractant/CXCL11 all showed antibacterial activity against S. pyogenes, and inhibition of MIG/CXCL9 expression reduced the antibacterial activity at the surface of inflamed pharyngeal cells. S. pyogenes of the clinically important M1 serotype secrets the protein streptococcal inhibitor of complement ( SIC), which inhibited the antibacterial activity of the chemokines. As exemplified by S. pyogenes pharyngitis, the data identify a novel innate defense mechanism against invasive bacteria on epithelial surfaces.

Item Type: Article
Faculty \ School: Faculty of Science > School of Pharmacy
UEA Research Groups: Faculty of Science > Research Groups > Pharmaceutical Cell Biology (former - to 2017)
Faculty of Science > Research Groups > Molecular and Tissue Pharmacology
Depositing User: Rachel Smith
Date Deposited: 31 May 2011 11:37
Last Modified: 24 Oct 2022 01:19
DOI: 10.1086/510857

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