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Egesten, Arne, Eliasson, Mette, Johansson, Helena M., Olin, Anders I., Mörgelin, Matthias, Mueller, Anja 
ORCID: https://orcid.org/0000-0003-0774-0434, Pease, James E., Frick, Inga-Maria and Björck, Lars
(2007)
The CXC chemokine MIG/CXCL9 is important in innate immunity against Streptococcus pyogenes.
Journal of Infectious Diseases, 195 (5).
pp. 684-693.
ISSN 0022-1899
Abstract
Pharyngitis caused by Streptococcus pyogenes is one of the most common bacterial infections in humans and is also a starting point for invasive S. pyogenes infection. Here, we describe that tonsil fluid from patients with streptococcal pharyngitis contains high amounts of the interferon ( IFN)-dependent CXC chemokine known as monokine induced by IFN-gamma ( MIG)/CXCL9. Also in vitro, inflamed pharyngeal epithelium produced large amounts of MIG/CXCL9 in the presence of bacteria. The CXC chemokines MIG/CXCL9, IFN-inducible protein-10/CXCL10, and IFN-inducible T cell alpha-chemoattractant/CXCL11 all showed antibacterial activity against S. pyogenes, and inhibition of MIG/CXCL9 expression reduced the antibacterial activity at the surface of inflamed pharyngeal cells. S. pyogenes of the clinically important M1 serotype secrets the protein streptococcal inhibitor of complement ( SIC), which inhibited the antibacterial activity of the chemokines. As exemplified by S. pyogenes pharyngitis, the data identify a novel innate defense mechanism against invasive bacteria on epithelial surfaces.
| Item Type: | Article |
|---|---|
| Faculty \ School: | Faculty of Science > School of Pharmacy |
| UEA Research Groups: | Faculty of Science > Research Groups > Pharmaceutical Cell Biology (former - to 2017) Faculty of Science > Research Groups > Molecular and Tissue Pharmacology |
| Depositing User: | Rachel Smith |
| Date Deposited: | 31 May 2011 11:37 |
| Last Modified: | 24 Oct 2022 01:19 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/31567 |
| DOI: | 10.1086/510857 |
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