Novel resorcin[4]arenes as potassium-selective ion-channel and transporter mimics

Wright, Angela J., Matthews, Sarah E. ORCID: https://orcid.org/0000-0001-8821-0851, Fischer, Wolfgang B. and Beer, Paul D. (2001) Novel resorcin[4]arenes as potassium-selective ion-channel and transporter mimics. Chemistry - A European Journal, 7 (16). pp. 3474-3481. ISSN 0947-6539

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Abstract

A series of novel resorcin[4]arenes with extended it systems have been synthesised and developed as potassium-selective transporters. Resorcin[4]arenes that feature crown ether moieties function as efficient carriers of K+ across bulk liquid membranes showing enhanced selectivity over the other alkali metal ions relative to a model system (benzo[15]crown-5). Incorporation of functionalities suitable for pore formation, in addition to an extra annulus of aromatic residues, gives molecules which have remarkable ion-channel-mimicking behaviour in a biological lipid bilayer with outstanding K+/Na+ selectivity.

Item Type:	Article
Uncontrolled Keywords:	calix<4>arenes,ionophores,bilayers,membranes,host molecules,ion channels,planar lipid bilayer,alkali metals,bind bipyridinium,benzo crown-ether,resorcin[4]arenes,gramicidin
Faculty \ School:	Faculty of Science > School of Pharmacy
UEA Research Groups:	Faculty of Science > Research Groups > Medicinal Chemistry (former - to 2017) Faculty of Science > Research Groups > Chemical Biology and Medicinal Chemistry (former - to 2021)
Depositing User:	Rachel Smith
Date Deposited:	31 May 2011 10:24
Last Modified:	24 Oct 2022 03:48
URI:	https://ueaeprints.uea.ac.uk/id/eprint/31510
DOI:	10.1002/1521-3765(20010817)7:16<3474::AID-CHEM3474>3.0.CO;2-6

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