A biodegradable multiblock co-polymer derived from an alpha,omega-bis(methylamino)peptide and an alpha,omega-bis(oxiranylmethyl)poly(ethylene glycol)

Matthews, S. E., Pouton, C. W. and Threadgill, M. D. (2000) A biodegradable multiblock co-polymer derived from an alpha,omega-bis(methylamino)peptide and an alpha,omega-bis(oxiranylmethyl)poly(ethylene glycol). Journal of Controlled Release, 67 (2-3). pp. 129-139. ISSN 0168-3659

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Abstract

A novel peptide containing the lysosomally degradable sequence GlyPheLeuGly and a sequence-inverting unit has been prepared. This peptide presents the methylamino groups of sarcosine (N-methylglycine) at both termini for co-polymerisation with alpha,omega-bis(oxiranylmethoxy)poly(ethylene glycol) of mean M-w 1650. Gel permeation chromatographic analysis showed the presence of a mixture of oligomers. preliminary degradation studies showed that these oligomers are cleaved by cathepsin B, an important lysosomal enzyme. (C) 2000 Elsevier Science B.V. All rights reserved.

Item Type: Article
Uncontrolled Keywords: ethers,biodegradable,peptide,glypheleugly,prodrugs,copolymers,drug,derivatives,cathepsin b,polyethylene glycol,enzymatically degradable bonds,release,retro-inverso,carriers
Faculty \ School: Faculty of Science > School of Pharmacy
Depositing User: Rachel Smith
Date Deposited: 26 May 2011 12:04
Last Modified: 31 Oct 2019 14:08
URI: https://ueaeprints.uea.ac.uk/id/eprint/31441
DOI:

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