A biodegradable multiblock co-polymer derived from an alpha,omega-bis(methylamino)peptide and an alpha,omega-bis(oxiranylmethyl)poly(ethylene glycol)

Matthews, Susan E. ORCID: https://orcid.org/0000-0001-8821-0851, Pouton, Colin W. and Threadgill, Michael D. (2000) A biodegradable multiblock co-polymer derived from an alpha,omega-bis(methylamino)peptide and an alpha,omega-bis(oxiranylmethyl)poly(ethylene glycol). Journal of Controlled Release, 67 (2-3). pp. 129-139. ISSN 0168-3659

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Abstract

A novel peptide containing the lysosomally degradable sequence GlyPheLeuGly and a sequence-inverting unit has been prepared. This peptide presents the methylamino groups of sarcosine (N-methylglycine) at both termini for co-polymerisation with alpha,omega-bis(oxiranylmethoxy)poly(ethylene glycol) of mean M-w 1650. Gel permeation chromatographic analysis showed the presence of a mixture of oligomers. preliminary degradation studies showed that these oligomers are cleaved by cathepsin B, an important lysosomal enzyme. (C) 2000 Elsevier Science B.V. All rights reserved.

Item Type:	Article
Uncontrolled Keywords:	ethers,biodegradable,peptide,glypheleugly,prodrugs,copolymers,drug,derivatives,cathepsin b,polyethylene glycol,enzymatically degradable bonds,release,retro-inverso,carriers
Faculty \ School:	Faculty of Science > School of Pharmacy
UEA Research Groups:	Faculty of Science > Research Groups > Chemical Biology and Medicinal Chemistry (former - to 2021) Faculty of Science > Research Groups > Medicinal Chemistry (former - to 2017)
Depositing User:	Rachel Smith
Date Deposited:	26 May 2011 12:04
Last Modified:	05 May 2024 00:52
URI:	https://ueaeprints.uea.ac.uk/id/eprint/31441
DOI:	10.1016/S0168-3659(00)00203-0

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