Incidence and risk factors of paediatric rotavirus diarrhoea in northern Ghana

Navrongo Rotavirus Research Group (2003) Incidence and risk factors of paediatric rotavirus diarrhoea in northern Ghana. Tropical Medicine & International Health, 8 (9). pp. 840-846. ISSN 1360-2276

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Abstract

We measured the type-specific incidence of paediatric rotavirus diarrhoea in an area of northern Ghana. Over 1 year, diarrhoea 1717 episodes were identified, of which 677 (39%) were positive for rotavirus. Risk factors for rotavirus infection included old age, wasting, high Vesikari score and the episode occurring in the dry season. Rotavirus-positive episodes tended to be more acute, causing vomiting and greater dehydration, and were more likely to require hospitalization. The incidence was 0.089 episodes per person-year for all diarrhoea, and 0.035 for rotavirus diarrhoea. The observed incidence decreased markedly with distance from the nearest health centre, suggesting a large unobserved burden. G2P[6], G3P[4] and G9P[8] made up more than half the genotypes detected, but the remainder were diverse. There is a large burden of rotavirus diarrhoea, but the effectiveness of future vaccines could be diluted by the high polymorphism of the virus, and the difficulty of reaching remote populations.

Item Type:	Article
Uncontrolled Keywords:	sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User:	Rhiannon Harvey
Date Deposited:	19 May 2011 08:49
Last Modified:	14 Aug 2023 10:30
URI:	https://ueaeprints.uea.ac.uk/id/eprint/30931
DOI:	10.1046/j.1365-3156.2003.01097.x

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