Geographic information systems and genotyping in identification of rotavirus G12 infections in residents of an urban slum with subsequent detection in hospitalized children: Emergence of G12 genotype in South India

Ramani, Sasirekha, Banerjee, Indrani, Primrose Gladstone, Beryl, Sarkar, Rajiv, Selvapandian, David, Le Fevre, Andrea M., Jaffar, Shabbar, Iturriza-Gomara, Miren, Gray, James J., Estes, Mary K., Brown, David W. and Kang, Gagandeep (2007) Geographic information systems and genotyping in identification of rotavirus G12 infections in residents of an urban slum with subsequent detection in hospitalized children: Emergence of G12 genotype in South India. Journal of Clinical Microbiology, 45 (2). pp. 432-437. ISSN 0095-1137

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Abstract

Rotavirus infections by G12 strains in several countries have recently been described. In this study, we report the emergence of G12 strains in south India. Fourteen cases of G12 infection were identified between June and September 2005. G12 was seen in combination with P[6], P[8], or nontypeable P type. Nine cases, including five symptomatic infections and four asymptomatic infections, were identified as part of routine surveillance for rotavirus infections in a birth cohort in the community between June and July 2005. Significant temporal and time-space clustering of eight of these cases represents a possible recent introduction of a new rotavirus VP7 genotype. Previous rotavirus infections had been documented for six of the nine children in the community. In the following 2 months, five cases of G12 infection were identified among children presenting to a referral hospital with diarrhea. This is the first description of symptomatic and asymptomatic G12 infections in children in the community. The detection of G12 strains from different parts of the world in recent years suggests the possibility of its emergence as an important global genotype. Monitoring of cocirculating rotavirus strains and detection of emerging strains is important in the context of the availability of rotavirus vaccines.

Item Type:	Article
Uncontrolled Keywords:	sdg 11 - sustainable cities and communities ,/dk/atira/pure/sustainabledevelopmentgoals/sustainable_cities_and_communities
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User:	Rhiannon Harvey
Date Deposited:	18 May 2011 14:28
Last Modified:	21 Dec 2023 01:34
URI:	https://ueaeprints.uea.ac.uk/id/eprint/30852
DOI:	10.1128/JCM.01710-06

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