Comparative study of the epidemiology of rotavirus in children from a community-based birth cohort and a hospital in south India

Banerjee, Indrani, Ramani, Sasirekha, Primrose, Beryl, Moses, Prabhakar, Iturriza-Gomara, Miren, Gray, James J., Jaffar, Shabbar, Monica, Bindhu, Muliyil, Jaya Prakash, Brown, David W., Estes, Mary K. and Kang, Gagandeep (2006) Comparative study of the epidemiology of rotavirus in children from a community-based birth cohort and a hospital in south India. Journal of Clinical Microbiology, 44 (7). pp. 2468-2474. ISSN 0095-1137

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Abstract

Rotavirus gastroenteritis is the major cause of severe dehydrating diarrhea in children worldwide. This study compares rotavirus diarrhea in 351 children in a community-based cohort and 343 children admitted to a hospital during the same period. Clinical information and fecal specimens were obtained during diarrheal episodes. Fecal samples were screened for VP6 antigen, and the positive samples were G and P typed by reverse transcription-PCR. Rotavirus was detected in 82/1,152 (7.1%) episodes of diarrhea in the community and 94/343 (27.4%) cases in the hospital. The median age of affected children (7.5 versus 10.5 months) and the mean severity of symptoms (Vesikari score, 7.6 ± 3.4 versus 11 ± 2.5) were lower in the community. A larger proportion of children in the community were breast-fed than were children admitted to the hospital (73% versus 34.8%). In the community, the genotypes identified in symptomatic patients, in order of frequency, were G1 (36.5%), G10 (17.1%), G2 (15.9%), and G9 (7.3%) and mixed infections (7.3%). The most common G-P combinations were G1P[8], G2P[4], G1P[4], and G10P[11]. The distribution of G types from hospitalized children was G1 (46.8%), G9 (19.1%), G2 (8.5%), G10 (1.1%), and 4.3% mixed infections. The most common G-P combinations were G1P[8] and G9P[8]. This study documents significant genetic heterogeneity of rotaviruses in the community and the hospital. G10P[11] strains resembling a vaccine candidate strain caused disease in the community, indicating the need for careful epidemiological studies as well as safety studies for the vaccine candidates.

Item Type:	Article
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User:	Rhiannon Harvey
Date Deposited:	18 May 2011 14:01
Last Modified:	03 Nov 2023 01:43
URI:	https://ueaeprints.uea.ac.uk/id/eprint/30834
DOI:	10.1128/JCM.01882-05

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