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Riley, G. P. 
ORCID: https://orcid.org/0000-0001-5528-5611, Cox, M., Harrall, R. L., Clements, S. and Hazleman, B. L.
(2001)
Inhibition of tendon cell proliferation and matrix glycosaminoglycan synthesis by non-steroidal anti-inflammatory drugs in vitro.
The Journal of Hand Surgery: Journal of the British Society for Surgery of the Hand, 26 (3).
pp. 224-228.
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Abstract
The purpose of this study was to investigate the effects of some commonly used non-steroidal anti-inflammatory drugs (NSAIDs) on human tendon. Explants of human digital flexor and patella tendons were cultured in medium containing pharmacological concentrations of NSAIDs. Cell proliferation was measured by incorporation of 3H-thymidine and glycosaminoglycan synthesis was measured by incorporation of 35S-Sulphate. Diclofenac and aceclofenac had no significant effect either on tendon cell proliferation or glycosaminoglycan synthesis. Indomethacin and naproxen inhibited cell proliferation in patella tendons and inhibited glycosaminoglycan synthesis in both digital flexor and patella tendons. If applicable to the in vivo situation, these NSAIDs should be used with caution in the treatment of pain after tendon injury and surgery.
| Item Type: | Article |
|---|---|
| Faculty \ School: | Faculty of Science > School of Biological Sciences |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Groups > Musculoskeletal Medicine Faculty of Science > Research Groups > Cells and Tissues |
| Depositing User: | Users 2731 not found. |
| Date Deposited: | 18 May 2011 09:40 |
| Last Modified: | 17 Jan 2024 01:24 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/30756 |
| DOI: | 10.1054/jhsb.2001.0560 |
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