Mycothiol: synthesis, biosynthesis and biological functions of the major low molecular weight thiol in actinomycetes

Jothivasan, V. K. and Hamilton, C. J. (2008) Mycothiol: synthesis, biosynthesis and biological functions of the major low molecular weight thiol in actinomycetes. Natural Product Reports, 25 (6). pp. 1091-1117. ISSN 0265-0568

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Abstract

Actinomycetes produce mycothiol as their major low molecular weight thiol, which parallels the functions of glutathione found in prokaryotes and most Gram-negative bacteria. This review covers progress that has so far been made in terms of its distribution, biosynthesis and metabolic functions, as well as chemical syntheses of mycothiol and alternative substrates and inhibitors of mycothiol biosynthesis and mycothiol-dependent enzymes. 152 references are cited.

Item Type: Article
Uncontrolled Keywords: inositol monophosphatase,inhibitor,dependent formaldehyde dehydrogenase,reductase,disulfide,cysteine ligase mshc,dibromotyrosine alkaloid,s-conjugate amidase,corynebacterium-glutamicum,anti-sigma factor,streptomyces-coelicolor a3(2),mycobacterium-tuberculosis erdman
Faculty \ School: Faculty of Science > School of Pharmacy
Depositing User: Rachel Smith
Date Deposited: 18 May 2011 09:32
Last Modified: 22 Apr 2020 14:19
URI: https://ueaeprints.uea.ac.uk/id/eprint/30708
DOI: 10.1039/b616489g

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