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Qi, S. 
ORCID: https://orcid.org/0000-0003-1872-9572, Deutsch, D. and Craig, D. Q. M.
(2006)
An investigation into the interaction between taste masking fatty acid microspheres and alkaline buffer using thermal and spectroscopic analysis.
Journal of Pharmaceutical Sciences, 95 (5).
pp. 1022-1028.
ISSN 0022-3549
Abstract
Fatty acid-based microspheres may be used for the controlled delivery and taste masking of therapeutic agents, although the mechanisms involved in the release process are poorly understood. In this investigation, microspheres composed of high purity stearic and palmitic acid were prepared using a spray-chilling protocol. In addition, samples of binary fatty acid systems, fatty acid salts and acid-soaps were prepared to allow comparison with the microspheres. The interaction with alkaline buffer, into which release is known to be rapid, was studied using DSC and powder XRD with a view to examining the physicochemical changes undergone by the microspheres as a result of exposure to this medium. New species were identified for the postimmersion microsphere systems; similarities between the thermal and spectroscopic properties of these materials and the acid-soap references indicated the formation of acid-soaps during the exposure to the medium. The data indicate that simple exposure to buffer may result in the formation of acid soaps. This in turn has implications for understanding not only the release of drugs from the microspheres but also the biological fate of fatty acids on ingestion. (c) 2006 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 95:1022-1028, 2006
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | systems |
| Faculty \ School: | Faculty of Science > School of Pharmacy (former - to 2024) |
| UEA Research Groups: | Faculty of Science > Research Groups > Drug Delivery and Pharmaceutical Materials (former - to 2017) Faculty of Science > Research Groups > Pharmaceutical Materials and Soft Matter |
| Depositing User: | Rachel Smith |
| Date Deposited: | 16 May 2011 11:21 |
| Last Modified: | 24 Sep 2024 09:51 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/30491 |
| DOI: | 10.1002/jps.20596 |
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