An investigation into the release of cefuroxime axetil from taste-masked stearic acid microspheres. II. The effects of buffer composition on drug release

Robson, H., Craig, D. Q. M. and Deutsch, D. (2000) An investigation into the release of cefuroxime axetil from taste-masked stearic acid microspheres. II. The effects of buffer composition on drug release. International Journal of Pharmaceutics, 195 (1-2). pp. 137-145. ISSN 0378-5173

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Abstract

The influence of buffer composition on the release of cefuroxime axetil from stearic acid microspheres has been investigated, with particular emphasis on establishing the relationship between buffer composition and release at a single pH value. Studies of drug dissolution and release from spheres in pH 7.0 citrate phosphate buffer (CPB), boric acid buffer (BAB), phosphate buffer mixed (PBM) and Sorensens modified phosphate buffer (SMPB) indicated marked differences in release profile from the spheres, with an approximate rank order of SMPB > CPB approximate to BAB > PBM. The role of added sodium was then investigated by examining the release profiles in SMPB and PBM to which sodium ions had been added. Increases in the sodium content from approximate to 0.11 to 0.2 M were found to decrease the release rate for the SMPB, while increases from 0.007 to 1.0 M sodium in PBM resulted in a maximum release being seen for the systems containing 0.05 M sodium. Studies on surface disintegration, using scanning electron microscopy (SEM) and sodium uptake using flame emission spectroscopy, indicated an interrelationship between medium composition, disintegration and release. The data are discussed in terms of the possible mechanisms associated with drug release from these spheres. (C) 2000 Elsevier Science B.V. All rights reserved.

Item Type:	Article
Uncontrolled Keywords:	flame emission spectroscopy,acid,cefuroxime axetil,suspension,microsphere,efficacy,taste masking,stearic
Faculty \ School:	Faculty of Science > School of Pharmacy
Depositing User:	Rachel Smith
Date Deposited:	17 May 2011 08:56
Last Modified:	11 Sep 2023 16:30
URI:	https://ueaeprints.uea.ac.uk/id/eprint/30438
DOI:	10.1016/S0378-5173(99)00391-9

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