Osteoporosis associated with neutralizing autoantibodies against osteoprotegerin

Riches, Philip L., McRorie, Euan, Fraser, William D., Determann, Catherine, van't Hof, Rob and Ralston, Stuart H. (2009) Osteoporosis associated with neutralizing autoantibodies against osteoprotegerin. New England Journal of Medicine, 361 (15). pp. 1459-1465. ISSN 0028-4793

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Abstract

Autoantibodies against osteoprotegerin, which block the inhibitory effect of osteoprotegerin on signaling by the receptor activator of nuclear factor (NF)-kappaB (RANK), were identified in a man with celiac disease who presented with severe osteoporosis and high bone turnover. The osteoporosis did not respond to the treatment of his celiac disease but was completely reversed by bisphosphonate therapy. Autoantibodies against osteoprotegerin were detected in three additional patients with celiac disease. Such autoantibodies may be associated with the development of high-turnover osteoporosis, but whether autoantibodies against osteoprotegerin commonly contribute to the pathogenesis of osteoporosis in patients with celiac disease remains to be determined.

Item Type:	Article
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Musculoskeletal Medicine Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health
Depositing User:	Rhiannon Harvey
Date Deposited:	11 May 2011 08:40
Last Modified:	19 Oct 2023 00:37
URI:	https://ueaeprints.uea.ac.uk/id/eprint/30176
DOI:	10.1056/NEJMoa0810925

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