Sodi, R., Hazell, M.J., Durham, B.H., Rees, C., Ranganath, L.R. and Fraser, W. D. (2009) The circulating concentration and ratio of total and high molecular weight adiponectin in post-menopausal women with and without osteoporosis and its association with body mass index and biochemical markers of bone metabolism. Clinical Biochemistry, 42 (13-14). pp. 1375-1380. ISSN 1873-2933
Full text not available from this repository. (Request a copy)Abstract
Objectives: There is increasing evidence suggesting that adiponectin plays a role in the regulation of bone metabolism. Design and methods: This was a cross-sectional study of 34 post-menopausal women with and 37 without osteoporosis. All subjects had body mass index (BMI), bone mineral density (BMD), total-, high molecular weight (HMW)-adiponectin and their ratio, osteoprotegerin (OPG), a marker of bone resorption (βCTX) and formation (P1NP) measured. Results: We observed a positive correlation between BMI and BMD (r = 0.44, p < 0.001). When normalised for BMI, total-, HMW-adiponectin concentrations and HMW/total-adiponectin ratio were significantly lower in obese compared to lean subjects but there was no difference between those with or without osteoporosis. There were significant negative correlations between HMW/total-adiponectin ratio and BMI (r = − 0.27, p = 0.030) and with OPG (r = − 0.44, p < 0.001). Conclusions: Our data suggests that there is no significant difference in the circulating concentration of fasting early morning total- or HMW-adiponectin in post-menopausal women with or without osteoporosis. The correlation between HMW/total-adiponectin ratio and OPG may indicate that adiponectin could influence bone metabolism by altering osteoblast production of OPG thereby affecting osteoclasts mediated bone resorption.
Item Type: | Article |
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Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Groups > Musculoskeletal Medicine Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health |
Depositing User: | Rhiannon Harvey |
Date Deposited: | 11 May 2011 08:33 |
Last Modified: | 21 Mar 2024 14:30 |
URI: | https://ueaeprints.uea.ac.uk/id/eprint/30174 |
DOI: | 10.1016/j.clinbiochem.2009.06.003 |
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