Instantaneous, stoichiometric generation of powerfully reducing states of protein active sites using Eu(II) and polyaminocarboxylate ligands

Vincent, Kylie A., Tilley, Gareth J., Quammie, Nina C., Streeter, Ian, Burgess, Barbara K., Cheesman, Myles R. and Armstrong, Fraser A. (2003) Instantaneous, stoichiometric generation of powerfully reducing states of protein active sites using Eu(II) and polyaminocarboxylate ligands. Chemical Communications (20). pp. 2590-2591. ISSN 1359-7345

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Abstract

Addition of an equivalent of a polyaminocarboxylate ligand (L) to a solution of a redox protein and the aqua Eu2+ ion results in the instantaneous in situ generation of a very powerful reductant Eu-II-L that can rapidly drive an electron stoichiometrically onto a redox centre having an extremely negative reduction potential ( lower than -1 V): this is exemplified by straightforward generation of the superreduced state of the Fe-protein of nitrogenase.

Item Type:	Article
Faculty \ School:	Faculty of Science > School of Chemistry (former - to 2024)
UEA Research Groups:	Faculty of Science > Research Groups > Biophysical Chemistry (former - to 2017) Faculty of Science > Research Groups > Chemistry of Life Processes Faculty of Science > Research Centres > Centre for Molecular and Structural Biochemistry Faculty of Science > Research Groups > Chemistry of Light and Energy
Depositing User:	Rachel Smith
Date Deposited:	10 May 2011 10:33
Last Modified:	24 Sep 2024 10:13
URI:	https://ueaeprints.uea.ac.uk/id/eprint/30090
DOI:	10.1039/b308188e

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