A convenient and versatile method for the synthesis of protected guanidines

Guo, Zhao-Xia, Cammidge, Andrew N. and Horwell, David C. (2000) A convenient and versatile method for the synthesis of protected guanidines. Synthetic Communications, 30 (16). pp. 2933-2943. ISSN 0039-7911

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Abstract

Aromatic, aliphatic and sterically hindered amines react smoothly with commercially available N,N'-bis-BOC-S-methylisothiourea 2 in the presence of mercury chloride to give the protected guanidine in good yield. It is particularly noteworthy that 2 can also be employed in a straightforward, two-step synthesis of monoaryl internal guanidines.

Item Type:	Article
Faculty \ School:	Faculty of Science > School of Chemistry (former - to 2024)
UEA Research Groups:	Faculty of Science > Research Groups > Chemistry of Materials and Catalysis Faculty of Science > Research Groups > Chemistry of Light and Energy Faculty of Science > Research Groups > Synthetic Chemistry (former - to 2017)
Depositing User:	Rachel Smith
Date Deposited:	09 May 2011 14:58
Last Modified:	28 Mar 2025 04:56
URI:	https://ueaeprints.uea.ac.uk/id/eprint/30056
DOI:	10.1080/00397910008087443

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