A convenient and versatile method for the synthesis of protected guanidines

Guo, Z. X., Cammidge, A. N. and Horwell, D. C. (2000) A convenient and versatile method for the synthesis of protected guanidines. Synthetic Communications, 30 (16). pp. 2933-2943. ISSN 0039-7911

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Abstract

Aromatic, aliphatic and sterically hindered amines react smoothly with commercially available N,N'-bis-BOC-S-methylisothiourea 2 in the presence of mercury chloride to give the protected guanidine in good yield. It is particularly noteworthy that 2 can also be employed in a straightforward, two-step synthesis of monoaryl internal guanidines.

Item Type: Article
Faculty \ School: Faculty of Science > School of Chemistry
Depositing User: Rachel Smith
Date Deposited: 09 May 2011 14:58
Last Modified: 21 Apr 2020 21:15
URI: https://ueaeprints.uea.ac.uk/id/eprint/30056
DOI:

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