Modeling cardiovascular disease in the zebrafish

Chico, Timothy J. A., Ingham, Philip W. and Crossman, David C. (2008) Modeling cardiovascular disease in the zebrafish. Trends in Cardiovascular Medicine, 18 (4). pp. 150-155. ISSN 1873-2615

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Abstract

The zebrafish possesses a host of advantages that have established it as an excellent model of vertebrate development. These include ease of genetic manipulation and transgenesis, optical clarity, and small size and cost. Biomedical researchers are increasingly exploiting these advantages to model human disease mechanisms. Here we review the use of the zebrafish for cardiovascular research. We summarize previous studies with the use of this organism to model such processes as thrombosis, collateral vessel development, inflammation, cardiomyopathy, and cardiac regeneration, evaluate its promise for novel drug discovery, and consider where the zebrafish fits into the framework of existing cardiovascular models.

Item Type:	Article
Uncontrolled Keywords:	sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Norwich Clinical Trials Unit
Depositing User:	Rhiannon Harvey
Date Deposited:	09 May 2011 14:17
Last Modified:	14 Jul 2023 15:30
URI:	https://ueaeprints.uea.ac.uk/id/eprint/30042
DOI:	10.1016/j.tcm.2008.04.002

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