Energy metabolism in human renin-gene transgenic rats: does renin contribute to obesity?

Gratze, Petra, Boschmann, Michael, Dechend, Ralf, Qadri, Fatimunnisa, Malchow, Jeanette, Graeske, Sabine, Engeli, Stefan, Janke, Jürgen, Springer, Jochen, Contrepas, Aurelie, Plehm, Ralph, Klaus, Susanne, Nguyen, Genevieve, Luft, Friedrich C. and Muller, Dominik N. (2009) Energy metabolism in human renin-gene transgenic rats: does renin contribute to obesity? Hypertension, 53 (3). pp. 516-523. ISSN 1524-4563

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Abstract

Renin initiates angiotensin II formation and has no other known functions. We observed that transgenic rats (TGR) overexpressing the human renin gene (hREN) developed moderate obesity with increased body fat mass and glucose intolerance compared with nontransgenic Sprague-Dawley (SD) rats. The metabolic changes were not reversed by an angiotensin-converting enzyme inhibitor, a direct renin inhibitor, or by (pro)renin receptor blocker treatment. The obese phenotype in TGR(hREN) originated from higher food intake, which was partly compensated by increases in resting energy expenditure, total thermogenesis (postprandial and exercise activity), and lipid oxidation during the first 8 weeks of life. Once established, the difference in body weight between TGR(hREN) and SD rats remained constant over time. When restricted to the caloric intake of SD, TGR(hREN) developed an even lower body weight than nontransgenic controls. We did not observe significant changes in the cocaine and amphetamine-regulated transcript, pro-opiomelanocortin, both anorexigenic, or neuropeptide Y, orexigenic, mRNA levels in TGR(hREN) versus SD controls. However, the mRNA level of the agouti-related peptide, orexigenic, was significantly reduced in TGR(hREN) versus SD controls at the end of the study, which indicates a compensatory mechanism. We suggest that the human renin transgene initiates a process leading to increased and early appetite, obesity, and metabolic changes not related to angiotensin II. The mechanisms are independent of any currently known renin-related effects.

Item Type:	Article
Uncontrolled Keywords:	sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Gastroenterology and Gut Biology
Depositing User:	Rhiannon Harvey
Date Deposited:	05 May 2011 15:41
Last Modified:	18 Jun 2024 15:30
URI:	https://ueaeprints.uea.ac.uk/id/eprint/29948
DOI:	10.1161/HYPERTENSIONAHA.108.124966

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