Meta-analysis of experimental data concerning antimicrobial resistance gene transfer rates during conjugation

Hunter, Paul R. ORCID: https://orcid.org/0000-0002-5608-6144, Wilkinson, Dawn C., Catling, Louise A. and Barker, Gary C. (2008) Meta-analysis of experimental data concerning antimicrobial resistance gene transfer rates during conjugation. Applied and Environmental Microbiology, 74 (19). pp. 6085-6090. ISSN 0099-2240

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Abstract

This paper presents the results of a meta-analysis of published transfer rates of antimicrobial resistance genes. A total of 34 papers were identified, of which 28 contained rates estimated in relation to either donor or recipient bacterial counts. The published rates ranged from 10−2 to 10−9. Generalized linear modeling was conducted to identify the factors influencing this variation. Highly significant associations between transfer frequency and both the donor (P = 1.2 × 10−4) and recipient (P = 1.0 × 10−5) genera were found. Also significant was whether the donor and recipient strains were of the same genus (P = 0.023) and the nature of the genetic element (P = 0.0019). The type of experiment, in vivo or in vitro, approached statistical significance (P = 0.12). Parameter estimates from a general linear model were used to estimate the probability of transfer of antimicrobial resistance genes to potential pathogens in the intestine following oral ingestion. The mean logarithms of these probabilities are in the range of [−7.0, −3.1]. These probability distributions are suitable for use in the quantitative assessment of the risk of transfer of antimicrobial resistance genes to the intestinal flora of humans and animals.

Item Type:	Article
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Epidemiology and Public Health Faculty of Medicine and Health Sciences > Research Groups > Public Health and Health Services Research (former - to 2023) Faculty of Medicine and Health Sciences > Research Centres > Population Health
Depositing User:	Rhiannon Harvey
Date Deposited:	20 Apr 2011 14:05
Last Modified:	03 Nov 2023 01:42
URI:	https://ueaeprints.uea.ac.uk/id/eprint/29752
DOI:	10.1128/AEM.01036-08

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