Sparse Bayesian kernel survival analysis for modeling the growth domain of microbial pathogens

Cawley, G. C. ORCID: https://orcid.org/0000-0002-4118-9095, Talbot, N. L. C., Janacek, G. J. and Peck, M. W. (2006) Sparse Bayesian kernel survival analysis for modeling the growth domain of microbial pathogens. IEEE Transactions on Neural Networks, 17 (2). pp. 471-481. ISSN 1045-9227

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Abstract

Survival analysis is a branch of statistics concerned with the time elapsing before "failure," with diverse applications in medical statistics and the analysis of the reliability of electrical or mechanical components. We introduce a parametric accelerated life survival analysis model based on kernel learning methods that, at least in principal, is able to learn arbitrary dependencies between a vector of explanatory variables and the scale of the distribution of survival times. The proposed kernel survival analysis method is then used to model the growth domain of Clostridium botulinum, the food processing and storage conditions permitting the growth of this foodborne microbial pathogen, leading to the production of the neurotoxin responsible for botulism. A Bayesian training procedure, based on the evidence framework, is used for model selection and to provide a credible interval on model predictions. The kernel survival analysis models are found to be more accurate than models based on more traditional survival analysis techniques but also suggest a risk assessment of the foodborne botulism hazard would benefit from the collection of additional data.

Item Type:	Article
Faculty \ School:	Faculty of Science > School of Computing Sciences
UEA Research Groups:	Faculty of Science > Research Groups > Data Science and AI Faculty of Science > Research Groups > Computational Biology Faculty of Science > Research Groups > Centre for Ocean and Atmospheric Sciences
Depositing User:	EPrints Services
Date Deposited:	01 Oct 2010 13:41
Last Modified:	24 Sep 2024 09:46
URI:	https://ueaeprints.uea.ac.uk/id/eprint/2894
DOI:	10.1109/TNN.2005.863452

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