Bacteriophage treatment significantly reduces viable Clostridium difficile and prevents toxin production in an in vitro model system

Meader, Emma, Mayer, Melinda J., Gasson, Michael J., Steverding, Dietmar, Carding, Simon R. and Narbad, Arjan (2010) Bacteriophage treatment significantly reduces viable Clostridium difficile and prevents toxin production in an in vitro model system. Anaerobe, 16 (6). pp. 549-554. ISSN 1075-9964

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Abstract

Clostridium difficile is primarily a nosocomial pathogen, causing thousands of cases of antibiotic-associated diarrhoea in the UK each year. In this study, we used a batch fermentation model of a C. difficile colonised system to evaluate the potential of a prophylactic and a remedial bacteriophage treatment regime to control the pathogen. It is shown that the prophylaxis regime was effective at preventing the growth of C. difficile (p =

Item Type:	Article
Uncontrolled Keywords:	sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Medicine (former - to 2013) Faculty of Medicine and Health Sciences > Research Groups > Gastroenterology and Gut Biology
Depositing User:	Rhiannon Harvey
Date Deposited:	04 Apr 2011 18:43
Last Modified:	19 Dec 2024 00:41
URI:	https://ueaeprints.uea.ac.uk/id/eprint/27980
DOI:	10.1016/j.anaerobe.2010.08.006

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