Using capsaicin modified multiwalled carbon nanotube based electrodes and p-chloranil modified carbon paste electrodes for the determination of amines: Application to benzocaine and lidocaine

Kachoosangi, Roohollah T., Wildgoose, Gregory and Compton, Richard G. (2008) Using capsaicin modified multiwalled carbon nanotube based electrodes and p-chloranil modified carbon paste electrodes for the determination of amines: Application to benzocaine and lidocaine. Electroanalysis, 20 (23). pp. 2495-2500. ISSN 1521-4109

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Abstract

The utilization of the capsaicin modified carbon nanotube modified basal-plane pyrolytic graphite electrode or p-chloranil modified carbon paste electrodes are presented for the determination of pharmaceutical compounds containing amine functionality, such as benzocaine and lidocaine. In detection of benzocaine at a capsaicin modified electrode, the guaiacol functional group is irreversibly electrochemically oxidized to form the o-quinone derivative which then undergoes nucleophilic attack by the aromatic amine group in benzocaine via a 1,4-Michael addition mechanism forming a catechol-amine adduct. The electrochemically initiated formation of the capsaicin-benzocaine adduct causes a linear decrease in the voltammetric signal corresponding to capsaicin which correlates to the added concentration of benzocaine.

Item Type:	Article
Faculty \ School:	Faculty of Science > School of Chemistry
UEA Research Groups:	Faculty of Science > Research Groups > Physical and Analytical Chemistry (former - to 2017) Faculty of Science > Research Groups > Synthetic Chemistry (former - to 2017)
Depositing User:	Rachel Smith
Date Deposited:	29 Mar 2011 16:24
Last Modified:	16 Jan 2023 12:30
URI:	https://ueaeprints.uea.ac.uk/id/eprint/27483
DOI:	10.1002/elan.200804385

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