Lipoprotein biogenesis in Gram-positive bacteria: knowing when to hold 'em, knowing when to fold 'em.

Hutchings, MI, Palmer, T, Harrington, DJ and Sutcliffe, IC (2009) Lipoprotein biogenesis in Gram-positive bacteria: knowing when to hold 'em, knowing when to fold 'em. Trends in Microbiology, 17 (1). pp. 13-21. ISSN 0966-842X

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Abstract

Gram-positive bacterial lipoproteins are a functionally diverse and important class of peripheral membrane proteins. Recent advances in molecular biology and the availability of whole genome sequence data have overturned many long-held assumptions about the export and processing of these proteins, most notably the recent discovery that not all lipoproteins are exported as unfolded substrates through the general secretion pathway. Here, we review recent discoveries concerning the export and processing of these proteins, their role in virulence in Gram-positive bacteria and their potential as vaccine candidates or targets for new antimicrobials.

Item Type: Article
Faculty \ School: Faculty of Science > School of Biological Sciences
Related URLs:
Depositing User: Matthew Hutchings
Date Deposited: 12 Sep 2011 08:36
Last Modified: 21 Jul 2020 23:36
URI: https://ueaeprints.uea.ac.uk/id/eprint/27314
DOI: 10.1016/j.tim.2008.10.001

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