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ToolsHutchings, Matthew I., Palmer, Tracy, Harrington, Dean J. and Sutcliffe, Iain C. (2009) Lipoprotein biogenesis in Gram-positive bacteria: knowing when to hold 'em, knowing when to fold 'em. Trends in Microbiology, 17 (1). pp. 13-21. ISSN 0966-842X
Full text not available from this repository. (Request a copy)Abstract
Gram-positive bacterial lipoproteins are a functionally diverse and important class of peripheral membrane proteins. Recent advances in molecular biology and the availability of whole genome sequence data have overturned many long-held assumptions about the export and processing of these proteins, most notably the recent discovery that not all lipoproteins are exported as unfolded substrates through the general secretion pathway. Here, we review recent discoveries concerning the export and processing of these proteins, their role in virulence in Gram-positive bacteria and their potential as vaccine candidates or targets for new antimicrobials.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being |
| Faculty \ School: | Faculty of Science > School of Biological Sciences |
| UEA Research Groups: | Faculty of Science > Research Groups > Organisms and the Environment Faculty of Science > Research Groups > Molecular Microbiology |
| Depositing User: | Matthew Hutchings |
| Date Deposited: | 12 Sep 2011 08:36 |
| Last Modified: | 16 May 2023 00:13 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/27314 |
| DOI: | 10.1016/j.tim.2008.10.001 |
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