Investigation of zinc bis(1,4-didecylbenzo)-bis(2,3-pyrido) porphyrazine for application as photosensitizer in photodynamic therapy of cancer

Sakamoto, Keiichi, Ohno-Okumura, Eiko, Kato, Taku, Watanabe, Masaki and Cook, Michael J. (2008) Investigation of zinc bis(1,4-didecylbenzo)-bis(2,3-pyrido) porphyrazine for application as photosensitizer in photodynamic therapy of cancer. Metal-Based Drugs, 2008. ISSN 0793-0291

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Abstract

The phthalocyanine analogue containing nonperipheral long alkyl-substituted benzenoid rings and pyridine rings, zinc bis(1,4-didecylbenzo)-bis(2,3-pyrido) porphyrazine, was synthesized. Zinc bis(1,4-didecylbenzo)-bis(2,3-pyrido) porphyrazine reacted with dimethyl sulfate and monochloroacetic acid to produce their quaternized products and diethyl sulfate to produce the sulfo-substituted products. All quaternized and sulfo-substituted showed amphiphilic character. Identical peaks in cyclic voltammograms appeared for these products before and after quaternization. During the evaluation of zinc bis(1,4-didecylbenzo)-bis(2,3-pyrido) porphyrazine for its photodynamic therapy of cancer (PDT) efficacy by cancer cell culture, the light exposed dimethyl sulfate quaternized zinc bis(1,4-didecylbenzo)-bis(2,3-pyrido) porphyrazines in IU-002 cells produce cell disruption that can be detected as a decrease in fluorescence.

Item Type:	Article
Uncontrolled Keywords:	sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School:	Faculty of Science > School of Chemistry (former - to 2024)
Depositing User:	Rachel Smith
Date Deposited:	22 Mar 2011 13:11
Last Modified:	24 Sep 2024 09:35
URI:	https://ueaeprints.uea.ac.uk/id/eprint/26875
DOI:	10.1155/2008/392090

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