Tumor necrosis factor SNP haplotypes are associated with iron deficiency anemia in West African children

Atkinson, Sarah H., Rockett, Kirk A., Morgan, Gareth, Bejon, Philip A., Sirugo, Giorgio, O'Connell, Maria ORCID: https://orcid.org/0000-0002-0267-0951, Hanchard, Neil, Kwiatkowski, Dominic P. and Prentice, Andrew M. (2008) Tumor necrosis factor SNP haplotypes are associated with iron deficiency anemia in West African children. Blood, 112 (10). pp. 4276-4283. ISSN 0006-4971

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Abstract

Plasma levels of tumor necrosis factor-[alpha] (TNF-[alpha]) are significantly raised in malaria infection and TNF-[alpha] is thought to inhibit intestinal iron absorption and macrophage iron release. This study investigated putative functional single nucleotide polymorphisms (SNPs) and haplotypes across the major histocompatibility complex (MHC) class III region, including TNF and its immediate neighbors nuclear factor of kappa light polypeptide gene enhancer in B cells (lkappaBL), inhibitor-like 1 and lymphotoxin alpha (LTA), in relation to nutritional iron status and anemia, in a cohort of 780 children across a malaria season. The prevalence of iron deficiency anemia (IDA) increased over the malaria season (P < .001). The TNF–308 AA genotype was associated with an increased risk of iron deficiency (adjusted OR 8.1; P = .001) and IDA (adjusted OR 5.1; P = .01) at the end of the malaria season. No genotypes were associated with IDA before the malaria season. Thus, TNF appears to be a risk factor for iron deficiency and IDA in children in a malaria-endemic environment and this is likely to be due to a TNF-[alpha]–induced block in iron absorption

Item Type:	Article
Uncontrolled Keywords:	sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School:	Faculty of Science > School of Pharmacy (former - to 2024)
UEA Research Groups:	Faculty of Science > Research Groups > Pharmaceutical Cell Biology (former - to 2017) Faculty of Science > Research Groups > Molecular and Tissue Pharmacology
Depositing User:	Rachel Smith
Date Deposited:	17 Mar 2011 11:52
Last Modified:	24 Sep 2024 09:28
URI:	https://ueaeprints.uea.ac.uk/id/eprint/26501
DOI:	10.1182/blood-2008-06-162008

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