Exploring the relationship between cocrystal stability and symmetry: is Wallach's rule applicable to multi-component solids?

Friščić, Tomislav, Fabian, Laszlo, Burley, Jonathan C., Reid, David G., Duer, Melinda J. and Jones, William (2008) Exploring the relationship between cocrystal stability and symmetry: is Wallach's rule applicable to multi-component solids? Chemical Communications (14). pp. 1644-1646. ISSN 1364-548X

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Abstract

Comparison of structure and hydration stability of pairs of chiral and racemic binary cocrystals indicates that the racemic solid is more stable than the chiral one; we illustrate that this difference might arise from intermolecular (crystal packing) factors in one case, while intramolecular (molecular conformation) factors are more significant in the other.

Item Type:	Article
Faculty \ School:	Faculty of Science > School of Pharmacy (former - to 2024)
UEA Research Groups:	Faculty of Science > Research Groups > Drug Delivery and Pharmaceutical Materials (former - to 2017) Faculty of Science > Research Groups > Pharmaceutical Materials and Soft Matter
Depositing User:	Rachel Smith
Date Deposited:	15 Mar 2011 15:10
Last Modified:	24 Sep 2024 09:29
URI:	https://ueaeprints.uea.ac.uk/id/eprint/26269
DOI:	10.1039/b717532a

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