The use of co-crystals for the determination of absolute stereochemistry: An alternative to salt formation

Eccles, Kevin S., Deasy, Rebecca E., Fabian, Laszlo, Maguire, Anita R. and Lawrence, Simon E. (2011) The use of co-crystals for the determination of absolute stereochemistry: An alternative to salt formation. The Journal of Organic Chemistry, 76 (4). pp. 1159-1162. ISSN 0022-3263

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Abstract

Absolute stereochemistry of oils and viscous liquids can be difficult to determine. Co-crystallization involves generating a crystalline material consisting of more than one neutral compound. The combination of co-crystallization with both X-ray diffraction and chiral HPLC was particularly powerful in overcoming these difficulties for a series of chiral 3-arylbutanoic acids. Co-crystallization offers advantages over salt formation because co-crystals dissociate in solution, meaning identical HPLC conditions can be used for both the materials of interest and their co-crystals.

Item Type:	Article
Faculty \ School:	Faculty of Science > School of Pharmacy (former - to 2024)
UEA Research Groups:	Faculty of Science > Research Groups > Drug Delivery and Pharmaceutical Materials (former - to 2017) Faculty of Science > Research Groups > Pharmaceutical Materials and Soft Matter
Depositing User:	Rachel Smith
Date Deposited:	15 Mar 2011 16:18
Last Modified:	24 Sep 2024 09:02
URI:	https://ueaeprints.uea.ac.uk/id/eprint/26251
DOI:	10.1021/jo102148p

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